From the off Arsenal dominated the ball on a crisp north London evening, with the first chance falling to 17-year-old Bukayo Saka – making his full debut – who saw his 20-yard effort beaten away by Qarabag ‘keeper Vagner.
Moments later Mesut Ozil played in Lacazette, who took a touch to beat his marker before rifling home from the corner of the six-yard box.
When Maksim Medvedev had the opportunity to hit back for the visitors from a cross that found him at the far post, he was denied by a challenge by Sokratis Papasthathopoulos whose effortless defending set the tone for the rest of Arsenal’s evening.
Although the visitors’ attacking threat was minimal, they also had the chance to square up proceedings just past the hour when Araz Abdullayev was picked out in the 18-yard box by Abdellah Zoubir, but he fluffed his lines just moments after his introduction.
And in the 89th-minute, 17-year-old winger Bukayo Saka missed a chance to become Arsenal’s youngest goalscorer in Europe as he smashed a finish into the face of Qarabag goalkeeper Vagner.
With Sporting Lisbon beating Vorskla Poltava 3-0, the Group E table remained the same, with the Gunners advancing to the last 32 as winners, while Azerbaijan’s Qarabag finished fourth with three points from six games.
Next Arsenal play in the Premier League away to Southampton in a 13:30 GMT kick-off on Sunday.